Ek Hazaaron Mein Meri Behna Hain is set in the beautiful Rishikesh. This is a story of two sisters who love each other enough to share their life and breath with each other.

Maanvi and Jeevika were raised by their parents in the upscale city of Delhi. However, they are orphaned in childhood. After they lose their parents, they have to settle into a middle class, traditional family of Rishikesh, which is a stark contrast to their lives earlier.  They have to grow up stifling any demands they may have openly made earlier, and have to fit into a traditional mould.